Betydningen av komplementsystemet for aktivering av koagulasjon i en human fullblodsmodell for inflammasjon
- Prosjektnummer
- SFP1287-16
- Ansvarlig person
- Ole-Lars Brekke
- Institusjon
- Nordlandssykehuset
- Prosjektkategori
- ph.d.-stipend
- Helsekategori
- Blood, Infection, Inflammatory and immune system
- Forskningsaktivitet
- 2. Aetiology, 3. Prevention
Brukerne som er friske blodgivere har deltatt og hatt mulighet til å påvirke, utvikle og endre prosjektet. De har også fått informasjon om resultater i prosjektet
Brukerne (blodgiverne) har hatt mulighet til å påvirke prosjektet.
Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood.
Mol Immunol 2019 10;114():139-148. Epub 2019 jul 25
PMID: 31352230
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.
Clin Exp Immunol 2019 04;196(1):97-110. Epub 2018 des 19
PMID: 30444525 - Inngår i doktorgradsavhandlingen
Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway.
Mol Genet Metab 2019 Nov;128(3):254-270. Epub 2018 des 10
PMID: 30583995
Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII.
Acta Biomater 2017 Aug;58():158-167. Epub 2017 mai 30
PMID: 28576714
Systemic inflammation in acute intermittent porphyria: a case-control study.
Clin Exp Immunol 2017 Mar;187(3):466-479. Epub 2016 des 15
PMID: 27859020
C1-inhibitor efficiently delays clot development in normal human whole blood and inhibits Escherichia coli-induced coagulation measured by thromboelastometry.
Thromb Res 2016 Jul;143():63-70. Epub 2016 apr 28
PMID: 27197075 - Inngår i doktorgradsavhandlingen
Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
J of Immunology, 2019 Aug 15; 203(4): 853–863. Published online 2019 Jul 3. doi: 10.4049/jimmunol.1900503
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli‐induced coagulation accompanied by Toll‐like receptor 4
Clin Exp Immunol. 2019 Apr; 196(1): 97–110. Published online 2018 Dec 19. doi: 10.1111/cei.13240
Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14.
Mol Immunol. 2019 Aug;112:131-139. doi: 10.1016/j.molimm.2019.03.014. Epub 2019 May 15.
Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Blood More Efficiently Than antagonizing.
The Journal of Infectious Disease 2016
The role of complement and Toll-like receptors in thromboinflammation
- Disputert:
- mai 2019
- Hovedveileder:
- Ole-Lars Brekke
- Anne Landsem Doktorgradsstipendiat
- Erik Waage Nielsen Prosjektdeltaker
- Tom Eirik Mollnes Forskningsgruppeleder
- Ole-Lars Brekke Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport, Helse Nord