Human lupus nephritis: An acquired error of chromatin metabolism – clinical consequence and future therapy
- Prosjektnummer
- SFP990-11
- Ansvarlig person
- Ole Petter Rekvig
- Institusjon
- Universitetssykehuset Nord-Norge HF
- Prosjektkategori
- Flerårig forskningsprosjekt
- Helsekategori
- Inflammatory and immune system
- Forskningsaktivitet
- 2. Aetiology
LMW heparin prevents increased kidney expression of proinflammatory mediators in (NZBxNZW)F1 mice.
Clin Dev Immunol 2013;2013():791262. Epub 2013 sep 17
PMID: 24151519
Lupus nephritis: enigmas, conflicting models and an emerging concept.
Mol Med 2013;19():161-9. Epub 2013 jul 24
PMID: 23752208
Low diagnostic and predictive value of anti-dsDNA antibodies in unselected patients with recent onset of rheumatic symptoms: results from a long-term follow-up Scandinavian multicentre study.
Scand J Rheumatol 2013;42(4):311-6. Epub 2013 mar 16
PMID: 23496224
Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis.
Am J Pathol 2013 Mar;182(3):688-700. Epub 2012 des 27
PMID: 23273922
Immunity and autoimmunity to dsDNA and chromatin--the role of immunogenic DNA-binding proteins and nuclease deficiencies.
Autoimmunity 2012 Dec;45(8):588-92. Epub 2012 sep 26
PMID: 23013317
Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of Toll like receptors and the Clec4e.
PLoS One 2012;7(3):e34080. Epub 2012 mar 30
PMID: 22479529
Autoantibodies in lupus: culprits or passive bystanders?
Autoimmun Rev 2012 Jun;11(8):596-603. Epub 2011 okt 25
PMID: 22041579
Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature in murine lupus nephritis.
Am J Pathol 2011 Sep;179(3):1120-8. Epub 2011 jun 30
PMID: 21723244
Chromatin as a target antigen in human and murine lupus nephritis.
Arthritis Res Ther 2011;13(2):214. Epub 2011 apr 18
PMID: 21542875
Circulating levels of chromatin fragments are inversely correlated with anti-dsDNA antibody levels in human and murine systemic lupus erythematosus.
Immunol Lett 2011 Aug;138(2):179-86. Epub 2011 apr 17
PMID: 21530588
Alterations in Wnt pathway activity in mouse serum and kidneys during lupus development.
Arthritis Rheum 2011 Feb;63(2):513-22.
PMID: 21280006
Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens.
Autoimmunity 2011 Aug;44(5):373-83. Epub 2011 jan 19
PMID: 21244336
Regulatory and pathogenetic mechanisms of autoantibodies in SLE.
Autoimmunity 2011 Aug;44(5):349-56. Epub 2011 jan 14
PMID: 21231891
BCR-ABL isoforms associated with intrinsic or acquired resistance to imatinib: more heterogeneous than just ABL kinase domain point mutations?
Med Oncol 2011 Jan. Epub 2011 jan 8
PMID: 21221851
Heparin exerts a dual effect on murine lupus nephritis by enhancing enzymatic chromatin degradation and preventing chromatin binding in glomerular membranes.
Arthritis Rheum 2011 Apr;63(4):1065-75.
PMID: 21190297
Nuclease deficiencies promote end-stage lupus nephritis but not nephritogenic autoimmunity in (NZB × NZW) F1 mice.
Immunol Cell Biol 2011 Jan;89(1):90-9. Epub 2010 jun 15
PMID: 20548325
Progressive lupus nephritis: Biological consequences of renal DNaseI gene silencing
- Disputert:
- oktober 2013
- Hovedveileder:
- Ole Petter Rekvig
Lupus nephritis: The role of renal DNaseI in the progression of the disease.
- Disputert:
- mai 2011
- Hovedveileder:
- Ole Petter Rekvig
Lupus nephritis and dermatitis: Pathogenesis and new therapeutic directions
- Disputert:
- januar 2011
- Hovedveileder:
- Ole Petter Rekvig
Impact of chromatin in lupus nephritis and lupus dermatitis.
- Disputert:
- juni 2011
- Hovedveileder:
- Elin Synnøve Mortensen
- Elin Synnøve Mortensen Prosjektdeltaker
- Dhivya Thiyagarajan Doktorgradsstipendiat
- Natalya Seredkina Postdoktorstipendiat
- Ole Petter Rekvig Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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